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In vitro fertilization (IVF) represents a remarkable breakthrough in reproductive technology, offering hope to countless individuals and couples facing fertility challenges. Especially in single gene diseases IVF and PGT could change millions of couples life. This intricate process involves several key stages, each meticulously designed to enhance the chances of conception.
1. Initial Consultation and Evaluation
- Comprehensive Assessment: The journey begins with an initial Prospective parents undergo a thorough evaluation, including medical histories, fertility assessments and genetics testing. Dr Mehmet Koc, Dr Ahmet Yesilyurt and Dr Umut Can Hasanoglu will discuss these results. This stage is pivotal for tailoring the treatment to the individual’s unique needs.
2. Ovarian Stimulation
- Hormonal Therapy: The core of IVF lies in stimulating the ovaries to produce multiple eggs. This is achieved through prescribed hormonal medications. The process is carefully monitored through ultrasound and blood tests to track egg development and optimize timing. This whole process usually takes 11-15 days.
3. Oocyte Pick-Up(Egg Retrieval)
- Minimally Invasive Procedure: Once the eggs mature, a minor surgical procedure is conducted. Using ultrasound guidance, a needle is inserted through the vaginal wall to gently extract the eggs from the ovaries. This step is typically done under sedation to ensure comfort.
4. Sperm Collection
- Sperm Preparation: Alongside egg retrieval, sperm is collected from the male partner. The sperm undergoes a preparation process to isolate the healthiest and most mobile sperm for fertilization. Sperm collection could be done before and freezed for later use if the husband has to go back to home country.
- In Vitro Conception: The harvested eggs and prepared sperm are combined in a laboratory setting to facilitate fertilization. In certain cases, intracytoplasmic sperm injection (ICSI) may be used, where a single sperm is directly injected into an egg to enhance fertilization chances.
6. Embryo Development and PGT
- Laboratory Growth: Post-fertilization, the embryos are closely monitored as they develop over several days in a controlled laboratory environment. This period is crucial for assessing the embryos’ health and In single gene disease patients we usually take some biopsies while the embryo develops and send them to genetic analysis.
7. Embryo Freeze
- After biopsies, developed embryos are freezed for later use and we’ll wait for genetic results.
- These embryos can wait a long time while freezed.
8. Embryo Transfer
- After genetic results, we start to prepare the uterus for embryo transfer. Preparation period usually takes around 21 days for the best uterus preparation
- Implantation Process: The most promising and healthy embryos are selected for transfer into the woman’s This procedure is usually quick and painless, involving a catheter that is passed through the cervix to place the embryos.
9. Post-Transfer Monitoring
- Pregnancy Testing: Following the embryo transfer, patients typically wait for about two weeks before undergoing a pregnancy test. This period can be emotionally challenging, filled with anticipation and hope.
IVF, while technologically advanced, is not a guaranteed path to pregnancy. Success rates vary based on numerous factors, including age, underlying fertility issues, and specific health conditions. However, for many single gene disease patients, it remains a beacon of hope, a testament to medical innovation in the quest for parenthood.